Modelling inheritance in pedigrees and populations, spring 2010
Modelling inheritance in pedigrees and populations, spring 2010
Lecturer
Scope
4 cu - 6 cu
Type and prerequisites
Advanced studies, no formal prerequisites. The course is tailored for Bioinformatics Master program (MBI) students and suitable to all students interested in population genetics and genomics, pedigree and haplotype inference, coalescence (see below).
Time schedule
Tue 19. Jan, 14-18 in room B120.
Tue 26. Jan - 23. Feb 14-16 in room B120, 16-18 in computer class B221 (Jussi Kollin, jussi.kollin at cs.helsinki.fi).
Tue 2. March 14-17 in room B120, homework (other than computer class execises) presentations.
Exams
There will be no exam. Grading is based on computer exercise reports, home assignments and literature surveys (scope 4-6cu).
Grading is fail/pass or, if desired, 1-5.
Contents of lectures, computer class exercises, and homework
The course is about population genetics, evolutionary factors which shape population structures, coalescence, haplotypes, an emphasis is in human populations, data analysis and simulation methods which lead to understanding human population genomic structures and human diseases (the course is not, however, a disease gene mapping course).
Week | Lectures | Recent review papers on the lecture topics |
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1 | |||
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3 |
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4 | Lectures on haplotypes, LD, coalescence continue |
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5 | mtDNA haplotypes and demo: ´Median joining haplotypes´ |
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6 | Human population genetics, Fst, differentiation, Wright-Fisher cont |
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Week | Computer class | To do before next computer class session |
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1 |
| , ,, |
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2 | Results from | Work for some preliminary results from |
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3 | Preliminary results from | Work further with assignment 1b, population comparisons etc. |
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4 | A look at assignment 1b, what is the situation now. |
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5 |
| Submit results from assignment 1b to Student page |
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6 | Results from assignment 1b. | Submit results from assignment 2 to Student page |
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7 | Results from assignment 2 |
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Student page
Registration
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