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1 = Statistical methods in genetic epidemiology and gene mapping, fall 2007 =
2
3 === Lecturer ===
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5 [[prof. Elja Arjas>>doc:mathstatHenkilokunta.Arjas, Elja]]
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7 === Scope ===
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9 6/8 cu.
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11 === Type ===
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13 Advanced studies.
14
15 === Prerequisites ===
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17 The course requires reasonable fluency in probability calculus, as well as understanding of the basic ideas underlying statistical inference and testing. It is also helpful, but not an absolute requirement, to have some previous familiarity with the main principles of genetic inheritance, particularly with Mendelian segregation.
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19 === Lectures ===
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21 Period I, Monday 10-12 in room B120, Thursday 12-14 in room C123 (both in Exactum).
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23 The lectures start on Monday, Sept. 10.
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25 === Contents ===
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27 The course will cover the main points from the monograph
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29 Duncan C. Thomas: Statistical Methods in Genetic Epidemiology, Oxford University Press, 2004
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31 Table of Contents:
32 ~1. Overview of Genetic Epidemiology
33 2. Basic Concepts of Molecular Genetics
34 3. Principles of Mendelian Inheritance
35 4. Basic Epidemiological and Statistical Principles
36 5. Familial Aggregation
37 6. Segregation Analysis
38 7. Linkage Analysis
39 8. Principles of Population Genetics
40 9. Testing Candidate Gene Associations
41 10. Linkage Disequilibrium Mapping
42 ~11. Gene Characterization
43 12. Tying it all together: The Genetic Epidemiology of Colorectal Cancer
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45 === Requirements for course completion ===
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47 Final exam, worth 6 ECTS credits, on November 14, from 16-20 o'clock in auditorium A111, Exactum.
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49 The following subjects are required at the exam:
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51 * Central points of chapters 3 (Principles of Mendelian inheritance) and 4 (Basic epidemiologic and statistical principles)
52 * Chapter 5 (Familial aggregation), pages 95-99, 104-110
53 * Chapter 6 (Segregation analysis), pages 137-148, 153-157
54 * Chapter 7 (Linkage analysis), pages 167-187, 191-196, 200-211
55 * Chapter 8 (Principles of population genetics), sivut 227-244, 247-252
56 * Chapter 9 (Testing candidate gene associations), sivut 253-264
57 * Chapter 10 (Linkage equilibrium mapping), sivut 283-286.
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59 By completing an individual study project one can earn 2 additional ECTS credits.