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 Weeks 4, 5 

There will not be a session 18. Feb. and there is more information in Moodle! To compensate this, there will be sessions Mon 22. Feb. 12-14, Wed 24. Feb. 12-14 and Thu 25. Feb 14-18. These sessions will not include any lectures, just practical advise for those who want to come. You can also ask for help by Moodle, or by email (sirkka-liisa.varvio at helsinki.fi)

• Choose one assignment. 4.1. and 4.2. are data-analysis assignments, by using the software DnaSP 5.10.1 (Manual) to get familiar with  polymorphisms as well as some key concepts. If you don´t want to do practical data-analysis, choose 4.3. and write an essay.  
   
• Assignment 4.1.  
  

  • •  HLA_DRB1_freqtable.xlsx , HLA_DRB1_alleles.txt    (Note that you don´t need these two files as the population sample files are ready for analyses)
      

    •  Czech.txt,  Portug.txt, Swed.txt, Bari.txt, Chile.txt, Xavant.txt, Camero.txt, Oromo.txt, Pygmi.txt
• Assignment 4.2.
  • •  USA_before_vacc.txt, USA_after_vacc.txt, Skand_before_vacc.txt, Skand_after_vacc.txt 
      
• Assignment 4.3. 
  • • Natural selection and infectious diseases in human populations
    • Recent human adaptation, genomic approaches, interpretations and insights
    • No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
    • Molecular sprandels, tests of adaptation at the genetic level
    • Selective sweeps in dogs