Statistical methods in medicine and epidemiology, fall 2011

News

The last lecture is on Tuesday (December 13). We start in
the computer class at 3:15 p.m. (see an extra R exercise below;
we will do this partly). After the computer class, a wrap-up
session in B120.

Survival regression in R

The second course exam will be on Thursday, December 15. We will
start at 4 p.m. sharp. The exam ends at 7 p.m. The exam will cover
the 2nd part of the course (see below for a detailed list of topics).

Lecturer

Kari Auranen

Scope

6-10 cu.

Type

Advanced studies

Prerequisites

Lecture summaries

1. The binary model. Conditional probability. Bayes formula. (Chapters 1 and 2)
2. Likelihood function (Chapter 3)
3. Estimation of survival. The hazard function. (Chapters 4 and 5)
4. Time. Competing risks. Censoring. (Chapters 6 and 7)
5. Approximating likelihoods. Statistical paradigms. (Chapters 8, 9 and 10)

6. P values (Chapter 11)

7. P values continued

8. Estimation of relative rates (Chapter 13)

9. Confounding. Stratification. Standardisation (Chapter 14 aand 15)

10. The lecture on confounding continued.

11. Case-control studies (Chapter 16)

12. Lecture. The lecture on case-control studies continued.

13. Matching

14. Part I: Poisson regression

14. Part II: Logistic regression

15. Samplesize

16. Hypothesis testing. Interaction

17. Model choice

18. Cox regression

19. Two articles on p values and statistical evidence
http://www.rni.helsinki.fi/~kja/epid11/article2.pdf

Errata

Exercises

1. Exercise

Data file (atresia.dat) The data matrix has 4 columns: individual ID, age at diagnosis, age at death or censoring,
failure indicator (1=death/0=censoring)

2. Exercise

3. Exercise

4. Exercise

5. Exercise

6.Exercise

7. Exercise (R practical)

8. Exercise

9. Exercise (R practical)

Answers to Exercise 1

Answers to Exercise 2

Answers to exercise 3

Answers to exercise 4

Answers to exercise 5

Answers to exercise 6

Answers to exercise 8

Datasets

CHD.dat
BCG.dat
BCGcasecontrol.dat
BCGmatched.dat
doseresponse.dat

Exams

The first course exam is on October 18 (Tuesday) at 4-7 p.m. Please
note the date which has changed from Thursday (Oct 20) to Tuesday (Oct 18).

The second course exam is on December 15 (Thursday) at 4-7 p.m. The
exam covers lectures 12-19, exercise 6-9 and the following chapters
from the textbook:

Chapters 16, 17, 18 (except 18.2), 19, 21, 22, 23 (except 23.4),24, 25, 26,29, 30.

Bibliography

Registration

Did you forget to register? What to do.

Exercise groups